Epigenetic Profiling of Oral Cancer

نویسندگان

  • A. Santoro
  • G. Pannone
  • S. Papagerakis
  • P. Bufo
چکیده

A. Santoro1,2, G. Pannone1, S. Papagerakis5, R. Serpico3, A. Guida3, L. Lo Muzio4 and P. Bufo1 1Department of Surgical Sciences, Section of Pathological Anatomy and Cytopathology, University of Foggia, Foggia, 2Department of Surgical Sciences, Institute of Pathological Anatomy, University of Bari, Bari, 3Department of Oral Pathology, Orthodontics and Oral Surgery, Second University of Napoli, Napoli, 4Department of Surgical Sciences, Section of Oral Pathology, University of Foggia, Foggia, 5Department of Otolaryngology – Head and Neck Surgery and Oncology, Medical School University of Michigan Ann Arbor, Ann Arbor, MI, 1,2,3,4Italy 5USA

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Expression Profiling of Hspb1 and Tp53 Genes through RT-qPCR in Different Cancer Types of Canis familiaris

Background: Diagnostic molecular marker studies are in vogue to have insight of most prevalent animal diseases including cancer.Objectives: Gene expression profi ling of pro and anti-apoptotic genes was conducted in dog Lymphoma, CTVT, SCC, granuloma, perianal adenocarcinoma and mammary tumors.Materials and Methods: Cancerous tissue...

متن کامل

The importance of epigenetic modifications in cancer progression

Epigenetics are dynamic and inherited changes in the genome that occur independently of DNA sequencing. This phenomenon requires coherent interaction with various enzymes and other molecular components. Abnormal epigenetic changes can lead to the onset of improper gene expression and the promotion of tumorigenesis. Because epigenetic changes are prone to external and reversible factors, they ar...

متن کامل

The Role of Epigenetics in Cancer Drug Resistance

Cancer is caused by aberrant genetic and epigenetic changes in genes expression. DNA methylation, histone modification, and microRNAs gene deregulation are the most known epigenetic changes in different stages of cancer. Since every tumor has its own specific epigenome, any abnormal pattern is a potential biomarker for classification of different types of tumors. Despite, tumorigenesis, abnorma...

متن کامل

درمان سرطان بر پایه اپی ژنتیک

Introduction: Epigenetics involves the study of heritable changes in the regulation of gene activity and expression that are not dependent on gene sequence. Main mechanisms of epigenetic modifications are DNA methylation, Histone modification and Nucleosome positioning. Several studies have shown that these modifications are related to cancer initiation, progression or tumor metastasis. In cont...

متن کامل

Evaluation of epigenetic changes of liver tissue induced by oral administration of Titanium dioxide nanoparticles and possible protective role of Nigella Sativa oil, in adult male albino rats

Objective (s): Titanium dioxide nanoparticles (TiO2 NPs) have been recognized as biologically inert material and have been used in a multitude of applications. Nevertheless, the negative impact on the human health is not yet well understood. Aim of the work: The study attempted to evaluate the epigenetic changes of the genome, in the form of DNA methylation in liver tissue samples, resulting fr...

متن کامل

The significance of gene profiling in diagnosis the cause of drug resistance in cancer

Chemoresistance is one of the main obstacles to the success of cancer treatment and one of the most important causes of death in patients. In the last decade, progress in high-throughput technologies, including microarray, sequencing, and bioinformatics has greatly resulted in cancer gene profiling and identification of biomarkers for cancer prognosis and prediction. This has greatly improved t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012